Wilkes Barre was my first location in the US and I have stayed there for 2 1/2 years. The airport has very few international flights.
Pros:
Good for people who are local
Fast security and immigration
Less crowded
People are really friendly
Cons
Very few destinations (even in US) without a connection
Most flights from this airport are small
One of my flight did not even have a lavatory and had seating capacity of 14 :)
Overall, it is very near Pocono mountains. Northeastern PA is very good for vacationing (Skiing, rafting, trekking etc) If you are in Northeastern PA on vacation, this is better than coming via Philadelphia and taking a rental car.