We were using the iPhone 6 as our primary phone before our rather lengthy experiment for the sake of this review, and we remember that the iPhone 6s felt noticeably heavier when we first picked it up, and this difference really threw us off our game for the first 24 hours.
We imagine the experience would be pretty much the same if you switched from an iPhone 6 Plus to an iPhone 6s Plus. For a company thats obsessed with making its products thinner and lighter, shipping flagship products that are both heavier and thicker than their predecessors is an interesting decision, and one that may not have been taken lightly at Cupertino.