How extracellular cues are transduced to the nucleus is a fundamental issue in biology. The paralogous WW-domain proteins YAP ( Yes-associated protein) and TAZ ( transcriptional coactivator with PDZ-binding motif; also known as WWTR1, for WW-domain containingTAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation … By modulating TAZexpression in model cell lines, mouse embryonic fibroblasts, and primary MSCs in culture and in zebrafish in vivo, we observed alterations in osteogenic versus adipogenic potential …