Gabriel Van Helsing (Hugh Jackman) is a man cursed with a past he cannot recall and driven by a mission he cannot deny. Van Helsing roams the world an outcast, a fugitive, a loner, himself hunted by those who don’t understand the true nature of his calling. When dispatched to the shadowy world of Transylvania, Van Helsing finds a land still mired in its past... where legendary creatures of darkness come to life... a place ruled over by the evil, seductive and undefeatable vampire, Count Dracula (Richard Roxburgh). It is Dracula that Van Helsing has been sent to terminate.
Anna Valerious (Kate Beckinsale) is one of the last of a powerful royal family, now nearly annihilated by Dracula. A fearless hunter in her own right, Anna is bent on avenging her ancestors and ending an ancient curse by killing the vampire. Joined by a common foe, Van Hesling and Anna set out to destroy Dracula along with his empire of fear. But in challenging an enemy who never dies, Van Helsing uncovers a secret he never imagined and comes face to face with the unresolved mysteries of his own enshrouded past.